Vol 4 (April 25, 2026): AME Clinical Trials Review

Letter to the Editor 
Reply to: Ibrutinib plus venetoclax for patients with relapsed or refractory mantle cell lymphoma: an editorial on the phase 3 SYMPATICO trial
Michael Wang, Jutta K. Neuenburg, Constantine S. Tam
AME Clinical Trials Review  
2026;
4:
21
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Letter to the Editor 
Response to “Steroid-Limited Isatuximab-Based Quadruplet Therapy in Elderly, Transplant-Ineligible Multiple Myeloma: A REST Trial Commentary”
Frida Bugge Askeland, Fredrik Schjesvold
AME Clinical Trials Review  
2026;
4:
20
.
Editorial Commentary 
Revisiting CDK4/6 inhibition and SERDs: EMBER-3 and the path forward
Carlos Henrique Barrios, Tomás Reinert
AME Clinical Trials Review  
2026;
4:
19
.
Editorial Commentary 
Reframing the immunotherapy landscape in borderline resectable pancreatic ductal adenocarcinoma: progress or plateau?
Alice Cattelani, Isabella Frigerio
AME Clinical Trials Review  
2026;
4:
18
.
Editorial Commentary 
Current and around-the-corner therapies in platinum-resistant ovarian cancer: an insight into the ROSELLA study
Valentina Tuninetti, Giorgio Valabrega
AME Clinical Trials Review  
2026;
4:
17
.
Editorial Commentary 
Cachexia, cytokines, and caution: lessons from tocilizumab in advanced pancreatic ductal adenocarcinoma
Carolyn Moloney-Lineen, Devalingam Mahalingam
AME Clinical Trials Review  
2026;
4:
16
.
Editorial Commentary 
Not so fast—should neoadjuvant chemotherapy be routine in resectable pancreatic cancers?
Coyin Oh, Devalingam Mahalingam
AME Clinical Trials Review  
2026;
4:
14
.
Review Article 
A literature review and reflection on clinical trials: current challenges, future directions, and potential strategies to overcome practical barriers
Kaiping Zhang, Savvas Lampridis, Charles B. Simone II, Ionut Negoi, Yan Peng, Binghan Shang, Yao Lin, Yaling Cheng, Fanghui Yang, Vishal G. Shelat, Kamyar Kalantar-Zadeh
AME Clinical Trials Review  
2026;
4:
12
.